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Features of Skin Repair After 7PDO Embedding

May. 27, 2021

PDO Thread has high biocompatibility, can be absorbed, strong, strong, hydrophobic, flat and smooth, non-antigenic and pyrogenic, and can stimulate moderate skin reaction and new collagen synthesis.

Skin repair period

In the first stage, the microtrauma caused by needle penetration into the epidermis, dermis, and subcutaneous tissue is a signal that cells in the body begin to proliferate. The tissue damage produces vasoactive substances and causes local inflammation. Suture the wound can be completed within 2 to 5 minutes, and the edge of the wound can form a barrier to prevent further infection.

PDO Thread

PDO Thread

In the second stage, after capillary injury, platelets are activated to produce growth factors and coagulation factors. The damage and repair are usually completed within 1 to 2 minutes. This hemostasis process is completed by vasoconstriction and mechanical embolism caused by platelet aggregates. Platelet aggregation depends on adhesion. An oligosaccharide protein secreted by endothelial cells and platelets. The blood vessels began to relax after 3 to 5 minutes.

In the third stage, this is the first step to stimulate regeneration and synthesis, namely traumatic inflammation, local venule contraction and arteriole expansion, resulting in increased osmotic pressure, swelling of the dermal papilla, and temporary blood stasis.

In the fourth stage, a few hours after the operation, in order to prevent further bleeding or hematoma, the body stimulates fibrin contraction to form a red thrombus, which contains blood cells that can be captured by fibrin and platelet network, forming a coagulation area and tightening damage. At the edge of the blood vessel, the wound is closed.

In the fifth stage, mast cells produce a large amount of histamine and adrenaline, increase the permeability of the dermal capillary wall and cell membrane, and accelerate the metabolism and tissue material exchange process.

The sixth stage is to increase the blood volume of the venous system.

In stage 7, hypertension causes tissue congestion, including:

(1) Long-term stimulation of the peripheral nerves of the dermal papillary layer increases the resistance to venous blood return.

(2) Stimulate the axons in the embedding area.

(3) Causes platelet adhesion in the blood vessel area.

(4) Increase the release of catecholamines in the blood.

(5) Activate the renin-angiotensin system.